特異性

The mouse monoclonal antibody LZ598-10G9 recognizes lysozyme, a 17 kDa antibacterial enzyme, which is being used as a marker for the lineage diagnosis of acute leukemias.

抗原情報

Lysozyme is anti-bacterial enzyme found mainly in milk, saliva, tears, plasma, spleen, mucus, and leukocytes (e.g. in cytoplasmic granules of neutrophils). It damages bacterial cell walls by hydrolysis of 1,4-β-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. Lysozyme is part of the innate immune system. It protects wet body surfaces, such as conjunctiva. Reduced lysozyme levels have been associated with bronchopulmonary dysplasia in newborns. On the other hand high lysozyme blood levels produced for example by myelomonocytic leukemia cells can lead to kidney failure and low blood potassium.

利用方法

保存方法

Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.

安定性情報

Do not use after expiration date stamped on vial label.

レファレンス

• Strobl H, Knapp W: Myeloid cell‑associated lysosomal proteins as flow cytometry markers for leukocyte lineage classification. J·Biol·Regul·Homeost·Agents. 2004·Jul-Dec; 18(3‑4):335‑9. <·PMID:·15786701·>