特異性

The mouse monoclonal antibody IP26 recognizes a monomorphic determinant of TCR α/β antigen, the dominant subtype of T cell receptor expressed in human peripheral blood.

抗原情報

The antigen-specific T cell receptor (TCR) is composed of either α and β subunit, or γ and δ subunit. Majority of T cells present in the blood, lymph and secondary lymphoid organs express TCR α/β heterodimers, whereas the T cells expressing TCR γ/δ heterodimers are localized mainly in epithelial tissues and at the sites of infection. The subunits of TCR heterodimers are covalently bonded and in the endoplasmic reticulum they associate with CD3 subunits to form functional TCR-CD3 complex. Lack of expression of any of the chains is sufficient to stop cell surface expression.

利用方法

保存方法

Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.

安定性情報

Do not use after expiration date stamped on vial label.

レファレンス

• Chentouf M, Ghannam S, Bés C, Troadec S, Cérutti M, Chardés T: Recombinant anti‑CD4 antibody 13B8.2 blocks membrane‑proximal events by excluding the Zap70 molecule and downstream targets SLP‑76, PLC gamma 1, and Vav‑1 from the CD4‑segregated Brij 98 detergent‑resistant raft domains. J·Immunol. 2007·Jul·1; 179(1):409‑20. <·PMID:·17579062·>
• Croxford AL, Akilli-Ozturk O, Rieux-Laucat F, Förster I, Waisman A, Buch T: MHC‑restricted T cell receptor signaling is required for alpha beta TCR replacement of the pre T cell receptor. Eur·J·Immunol. 2008·Feb; 38(2):391‑9. <·PMID:·18203137·>
• Huet D, Bagot M, Loyaux D, Capdevielle J, Conraux L, Ferrara P, Bensussan A, Marie-Cardine A: SC5 mAb represents a unique tool for the detection of extracellular vimentin as a specific marker of Sezary cells. J·Immunol. 2006·Jan·1; 176(1):652‑9. <·PMID:·16365461·>
• Kuttruff S, Koch S, Kelp A, Pawelec G, Rammensee HG, Steinle A: NKp80 defines and stimulates a reactive subset of CD8 T cells. Blood. 2009·Jan·8; 113(2):358‑69. <·PMID:·18922855·>
• Levelt CN, Wang B, Ehrfeld A, Terhorst C, Eichmann K: Regulation of T cell receptor (TCR)‑beta locus allelic exclusion and initiation of TCR‑alpha locus rearrangement in immature thymocytes by signaling through the CD3 complex. Eur·J·Immunol. 1995·May; 25(5):1257‑61. <·PMID:·7774628·>
• Michie AM, Zúñiga-Pflücker JC: Regulation of thymocyte differentiation: pre‑TCR signals and beta‑selection. Semin·Immunol. 2002·Oct; 14(5):311‑23. <·PMID:·12220932·>
• Ortonne N, Huet D, Gaudez C, Marie-Cardine A, Schiavon V, Bagot M, Musette P, Bensussan A: Significance of circulating T‑cell clones in Sezary syndrome. Blood. 2006·May·15; 107(10):4030‑8. <·PMID:·16418328·>
• Sullivan BM, Coscoy L: Downregulation of the T‑cell receptor complex and impairment of T‑cell activation by human herpesvirus 6 u24 protein. J·Virol. 2008·Jan; 82(2):602‑8. <·PMID:·17977973·>
• von Boehmer H: T cell development and selection in the thymus. Bone·Marrow·Transplant. 1992; 9 Suppl 1:46‑8. <·PMID:·1324045·>