特異性

The mouse monoclonal antibody HP-3D9 recognizes CD94 antigen, a 70 kDa type II transmembrane glycoprotein expressed on NK cells, NK-T cells, and subsets of CD8+ T cells and gamma/delta T cells.

抗原情報

CD94 (KLRD1; killer cell lectin-like receptor D1) is a transmembrane glycoprotein of the C-type lectin family, which forms disulfide-linked heterodimers with NKG2A, B, C, E, H proteins, constituting functionally distinct receptors of NK cells and related cell types. CD94/NKG2A and CD94/NKG2B heterodimers serve as inhibitory, whereas CD94/NKG2C and CD94/NKG2E as activating receptors. The ligand for CD94/NKG2 complexes has been identified as HLA-E. Extent of CD94 expression on NK cell surface can be used to demonstrate their progress through the differentiation process.

利用方法

保存方法

Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.

安定性情報

Do not use after expiration date stamped on vial label.

レファレンス

• Bovenschen HJ, Van De Kerkhof PC, Gerritsen WJ, Seyger MM: The role of lesional T cells in recalcitrant psoriasis during infliximab therapy. Eur·J·Dermatol. 2005·Nov-Dec; 15(6):454‑8. <·PMID:·16280298·>
• Hallermalm K, Seki K, De Geer A, Motyka B, Bleackley RC, Jager MJ, Froelich CJ, Kiessling R, Levitsky V, Levitskaya J: Modulation of the tumor cell phenotype by IFN‑gamma results in resistance of uveal melanoma cells to granule‑mediated lysis by cytotoxic lymphocytes. J·Immunol. 2008·Mar·15; 180(6):3766‑74. <·PMID:·18322182·>
• Ntrivalas EI, Kwak-Kim JY, Gilman-Sachs A, Chung-Bang H, Ng SC, Beaman KD, Mantouvalos HP, Beer AE: Status of peripheral blood natural killer cells in women with recurrent spontaneous abortions and infertility of unknown aetiology. Hum·Reprod. 2001·May; 16(5):855‑61. <·PMID:·11331628·>
• Phillips JH, Chang C, Mattson J, Gumperz JE, Parham P, Lanier LL: CD94 and a novel associated protein (94AP) form a NK cell receptor involved in the recognition of HLA‑A, HLA‑B, and HLA‑C allotypes. Immunity. 1996·Aug; 5(2):163‑72. <·PMID:·8769479·>
• Romero P, Ortega C, Palma A, Molina IJ, Peña J, Santamaría M: Expression of CD94 and NKG2 molecules on human CD4(+) T cells in response to CD3‑mediated stimulation. J·Leukoc·Biol. 2001·Aug; 70(2):219‑24. <·PMID:·11493613·>
• Seo N, Tokura Y, Ishihara S, Takeoka Y, Tagawa S, Takigawa M: Disordered expression of inhibitory receptors on the NK1‑type natural killer (NK) leukaemic cells from patients with hypersensitivity to mosquito bites. Clin·Exp·Immunol. 2000·Jun; 120(3):413‑9. <·PMID:·10844517·>
• Wada H, Matsumoto N, Maenaka K, Suzuki K, Yamamoto K: The inhibitory NK cell receptor CD94/NKG2A and the activating receptor CD94/NKG2C bind the top of HLA‑E through mostly shared but partly distinct sets of HLA‑E residues. Eur·J·Immunol. 2004·Jan; 34(1):81‑90. <·PMID:·14971033·>
• Yu J, Mao HC, Wei M, Hughes T, Zhang J, Park IK, Liu S, McClory S, Marcucci G, Trotta R, Caligiuri MA: CD94 surface density identifies a functional intermediary between the CD56bright and CD56dim human NK‑cell subsets. Blood. 2010·Jan·14; 115(2):274‑81. <·PMID:·19897577·>