特異性

The mouse monoclonal antibody TRIM-04 recognizes TRIM (T cell receptor-interacting molecule) antigen, a 30 kDa adaptor protein expressed by T cells.

抗原情報

TRIM (T cell receptor-interacting molecule), also known as TRAT1 (T cell receptor associated transmembrane adaptor 1) is a 30 kDa protein expressed by T cells as a cystein-linked homodimer. It associates with TCR-CD3-ζ-chain complex and becomes phosphorylated by Src-family kinases. TRIM is potentially involved in negative regulation of TCR-mediated signaling, but its role remains unclear.

利用方法

保存方法

Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.

安定性情報

Do not use after expiration date stamped on vial label.

レファレンス

• Horejsí V, Zhang W, Schraven B: Transmembrane adaptor proteins: organizers of immunoreceptor signalling. Nat·Rev·Immunol. 2004·Aug; 4(8):603‑16. <·PMID:·15286727·>
• Huynh T, Wurch A, Bruyns E, Korinek V, Schraven B, Eichmann K: Developmentally regulated expression of the transmembrane adaptor protein trim in fetal and adult T cells. Scand·J·Immunol. 2001·Jul-Aug; 54(1‑2):146‑54. <·PMID:·11439161·>
• Kirchgessner H, Dietrich J, Scherer J, Isomaki P, Korinek V, Hilgert I, Bruyns E, Leo A, Cope AP, Schraven B: The transmembrane adaptor protein TRIM regulates T cell receptor (TCR) expression and TCR‑mediated signaling via an association with the TCR zeta chain. J·Exp·Med. 2001·Jun·4; 193(11):1269‑84. <·PMID:·11390434·>
• Simeoni L, Smida M, Posevitz V, Schraven B, Lindquist JA: Right time, right place: the organization of membrane proximal signaling. Semin·Immunol. 2005·Feb; 17(1):35‑49. <·PMID:·15582487·>
• Tedoldi S, Paterson JC, Hansmann ML, Natkunam Y, Rudiger T, Angelisova P, Du MQ, Roberton H, Roncador G, Sanchez L, Pozzobon M, Masir N, Barry R, Pileri S, Mason DY, Marafioti T, Horejsi V: Transmembrane adaptor molecules: a new category of lymphoid‑cell markers. Blood. 2006·Jan·1; 107(1):213‑21. <·PMID:·16160011·>