CyFlow CD253 Low Endotoxin (RUO)
| 品番 | AM151429 | ||
|---|---|---|---|
| 抗体名 | Anti-Hu CD253 LOW END,2E5 | ||
| 包装単位 | 0.1 mg | ||
| 濃度 | 1 mg/ml | ||
| 推奨使用量 | - | ||
| 容量 | 0.1 ml | ||
| 関連製品 (アイソタイプコントロール) |
Mouse IgG1 Low Endotoxin (AK478344) |
||
| 反応性|交差吸着 | Human | レーザー | - |
| 抗原 | CD253, TRAIL, Apo2L | 最大蛍光波長 | - |
| クローン | 2E5 | 最大励起波長 | - |
| ホスト | Mouse | 標識/Format | Low Endotoxin |
| アイソタイプ | IgG1 | 研究分野 | Immunophenotyping | Apoptosis |
| クローナリティ | monoclonal | アプリケーション | - |
Anti-Hu CD253 LOW END,2E5
特異性
The mouse monoclonal antibody 2E5 recognizes CD253 (TRAIL) antigen, a 21 kDa cytotoxic protein, activator of rapid apoptosis in tumor cells. TRAIL is mainly expressed in spleen, lung, prostate and also in many other tissues.
抗原情報
CD253 (TRAIL; TNF-Related Apoptosis Inducing Ligand or Apo2) is a type II membrane protein from the TNF family. TRAIL is a cytotoxic protein which activates rapid apoptosis in tumor cells, but not in normal cells. TRAIL-induced apotosis, is achieved through binding to two dealth-signaling receptors, DR4 (CD261 / TRAIL-R1) and DR5 (CD262 / TRAIL-R2).
利用方法
保存方法
Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
安定性情報
Do not use after expiration date stamped on vial label.
レファレンス
• Hyer ML, Croxton R, Krajewska M, Krajewski S, Kress CL, Lu M, Suh N, Sporn MB, Cryns VL, Zapata JM, Reed JC: Synthetic triterpenoids cooperate with tumor necrosis factor‑related apoptosis‑inducing ligand to induce apoptosis of breast cancer cells. Cancer·Res. 2005·Jun·1; 65(11):4799‑808. <·PMID:·15930300·>
• Plasilova M, Zivny J, Jelinek J, Neuwirtova R, Cermak J, Necas E, Andera L, Stopka T: TRAIL (Apo2L) suppresses growth of primary human leukemia and myelodysplasia progenitors. Leukemia. 2002·Jan; 16(1):67‑73. <·PMID:·11840265·>