特異性

The mouse monoclonal antibody TS1/8 recognizes CD2 antigen, a 50 kDa glycoprotein present on the human peripheral blood T lymphocytes and NK cells; also expressed by all thymocytes.

抗原情報

CD2 (LFA-2) belongs to T lymphocyte glycoproteins of immunoglobulin superfamily. Its interaction with CD58 stabilizes adhesion between T cells and antigen presenting or target cells. Relatively low affinity of CD2 to CD58 (as measured in solution) is compensated within the two-dimensional cell-cell interface to provide tight adhesion. Moreover, T cell activation induces increased CD2 expression and its lateral mobility, making easier contact between CD2 and CD58. Subsequently, T cell activation causes fixation of CD58-CD2 at sites of cell-cell contact, thereby strengthening intercellular adhesion. CD2 deficiency reduces intestinal inflammation and helps to control infection.

利用方法

保存方法

Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.

安定性情報

Do not use after expiration date stamped on vial label.

レファレンス

• Doussis IA, Gatter KC, Mason DY: CD68 reactivity of non‑macrophage derived tumours in cytological specimens. J·Clin·Pathol. 1993·Apr; 46(4):334‑6. <·PMID:·7684403·>
• Sanchez-Madrid F, Krensky AM, Ware CF, Robbins E, Strominger JL, Burakoff SJ, Springer TA: Three distinct antigens associated with human T‑lymphocyte‑mediated cytolysis: LFA‑1, LFA‑2, and LFA‑3. Proc·Natl·Acad·Sci·USA. 1982·Dec; 79(23):7489‑93. <·PMID:·6984191·>
• Vollger LW, Tuck DT, Springer TA, Haynes BF, Singer KH: Thymocyte binding to human thymic epithelial cells is inhibited by monoclonal antibodies to CD‑2 and LFA‑3 antigens. J·Immunol. 1987·Jan·15; 138(2):358‑63. <·PMID:·3098838·>
• Zhang B, Dai M, Li QJ, Zhuang Y: Tracking proliferative history in lymphocyte development with cre‑mediated sister chromatid recombination. PLoS·Genet. 2013·Oct; 9(10):e1003887. <·PMID:·24204301·>