特異性

The mouse monoclonal antibody SHIP-01recognizes SHIP-1 antigen, a phosphoinositide phosphatase largely confined to hematopoietic cells. Multiple forms of SHIP-1 have been reported with molecular weights of 110, 125, 130, 135 and 145 kDa.

抗原情報

SHIP-1 (SH2 domain containing inositol phosphatase-1) is a 5´inositol phosphatase that regulates cell responses in lymphocytes and myeloid cells by hydrolyzing the second messenger PI (3,4,5) trisphosphate. SHIP-1 is recruited upon engagement of both inhibitory and activatory receptors, such as FcγRIIB, FcγRIII, FcεRI or cytokine and growth factor receptors, and supresses PI3K-dependent signaling, down-regulates cell migration and invasion of transformed cells and phagocytosis. SHIP-1 also serves as a scaffold for the recruitment of other proteins to the plasma membrane.

利用方法

保存方法

Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.

安定性情報

Do not use after expiration date stamped on vial label.

レファレンス

• Ai J, Maturu A, Johnson W, Wang Y, Marsh CB, Tridandapani S: The inositol phosphatase SHIP‑2 down‑regulates FcgammaR‑mediated phagocytosis in murine macrophages independently of SHIP‑1. Blood. 2006·Jan·15; 107(2):813‑20. <·PMID:·16179375·>
• Harris SJ, Parry RV, Westwick J, Ward SG: Phosphoinositide lipid phosphatases: natural regulators of phosphoinositide 3‑kinase signaling in T lymphocytes. J·Biol·Chem. 2008·Feb·1; 283(5):2465‑9. <·PMID:·18073217·>
• Tarasenko T, Kole HK, Chi AW, Mentink-Kane MM, Wynn TA, Bolland S: T cell‑specific deletion of the inositol phosphatase SHIP reveals its role in regulating Th1/Th2 and cytotoxic responses. Proc·Natl·Acad·Sci·USA. 2007·Jul·3; 104(27):11382‑7. <·PMID:·17585010·>
• Xing W, Hamaguchi M: Effects of SHIP‑1 on MMP2 secretion and invasion of SR3Y1 cells. J·Genet·Genomics. 2007·Apr; 34(4):285‑93. <·PMID:·17498626·>