特異性

The mouse monoclonal antibody NOK-1 recognizes CD178 antigen, a 40 kDa transmembrane glycoprotein expressed on neutrophils, monocytes, and activated T and NK cells.

抗原情報

CD178 (Fas-L; Fas ligand or CD95L), a member of TNF family transmembrane glycoproteins, is responsible for induction of apoptosis in cells containing its receptor Fas/CD95. The CD178-mediated apoptosis pathway has been implicated in peripheral tolerance, tissue pathology, and maintenance of the immune privileged sites. Defects in this interaction may be related to some cases of systemic lupus erythematosus (SLE). CD178 was also described as a co-stimulatory receptor for T-cell activation in mice in vivo.

利用方法

保存方法

Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.

安定性情報

Do not use after expiration date stamped on vial label.

レファレンス

• Chopin D, Barei-Moniri R, Maillé P, Le Frére-Belda MA, Muscatelli-Groux B, Merendino N, Lecerf L, Stoppacciaro A, Velotti F: Human urinary bladder transitional cell carcinomas acquire the functional Fas ligand during tumor progression. Am·J·Pathol. 2003·Apr; 162(4):1139‑49. <·PMID:·12651606·>
• Ghadimi MP, Sanzenbacher R, Thiede B, Wenzel J, Jing Q, Plomann M, Borkhardt A, Kabelitz D, Janssen O: Identification of interaction partners of the cytosolic polyproline region of CD95 ligand (CD178). FEBS·Lett. 2002·May·22; 519(1‑3):50‑8. <·PMID:·12023017·>
• Ji J, Chen JJ, Braciale VL, Cloyd MW: Apoptosis induced in HIV‑1‑exposed, resting CD4+ T cells subsequent to signaling through homing receptors is Fas/Fas ligand‑mediated. J·Leukoc·Biol. 2007·Jan; 81(1):297‑305. <·PMID:·17056762·>
• Jodo S, Pidiyar VJ, Xiao S, Furusaki A, Sharma R, Koike T, Ju ST: Fas ligand (CD178) cytoplasmic tail is a positive regulator of Fas ligand‑mediated cytotoxicity. J·Immunol. 2005·Apr·15; 174(8):4470‑4. <·PMID:·15814666·>
• Kayagaki N, Kawasaki A, Ebata T, Ohmoto H, Ikeda S, Inoue S, Yoshino K, Okumura K, Yagita H: Metalloproteinase‑mediated release of human Fas ligand. J·Exp·Med. 1995·Dec·1; 182(6):1777‑83. <·PMID:·7500022·>