特異性

The mouse monoclonal antibody HP-3G10 recognizes CD161 antigen, a type II transmembrane C-type lectin receptor, expressed on the plasma membrane of NK cells, dendritic cells, activated monocytes and a subset of T cells as a disulphide-linked homodimer.

抗原情報

CD161 (Nkrp1; natural killer receptor protein 1 or Klrb1; killer cell lectin-like receptor subfamily b member 1) is a disulphide-linked homodimeric receptor, which is involved in regulation of NK cell and NKT cell function. It is expressed on rat NK cells, subset of T cells, dendritic cells, and activated monocytes. Although human CD161 is expressed as one isoform, the rat CD161 has three isoforms, referred to as CD161a, b, and c. These proteins contain C-terminal C-type lectin extracellular domain, a transmembrane domain, and N-terminal intracellular domain, which contains ITIM motif, such as CD161b, and displays inhibitory function, or does not contain ITIM motif, thus also not the inhibitory function, such as CD161a.

利用方法

保存方法

Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.

安定性情報

Do not use after expiration date stamped on vial label.

レファレンス

• Fogal B, Yi T, Wang C, Rao DA, Lebastchi A, Kulkarni S, Tellides G, Pober JS: Neutralizing IL‑6 reduces human arterial allograft rejection by allowing emergence of CD161(+) CD4(+) T regulatory cells. J·Immunol. 2011·Dec·15; 187(12):6268‑6280. <·PMID:·22084439·>
• Germain C, Meier A, Jensen T, Knapnougel P, Poupon G, Lazzari A, Neisig A, Hakansson K, Dong T, Wagtmann N, Galsgaard ED, Spee P, Braud VM: Induction of lectin‑like transcript 1 (LLT{01} protein cell surface expression by pathogens and interferon‑γ contributes to modulate immune responses. J·Biol·Chem. 2011·Nov·4; 286(44):37964‑75. <·PMID:·21930700·>
• Goetzl EJ, Huang MC, Kon J, Patel K, Schwartz JB, Fast K, Ferrucci L, Madara K, Taub DD, Longo DL: Gender specificity of altered human immune cytokine profiles in aging. FASEB·J. 2010·Sep; 24(9):3580‑9. <·PMID:·20453111·>
• Pozo D, Valés-Gómez M, Mavaddat N, Williamson SC, Chisholm SE, Reyburn H: CD161 (human NKR‑P1A) signaling in NK cells involves the activation of acid sphingomyelinase. J·Immunol. 2006·Feb·15; 176(4):2397‑406. <·PMID:·16455998·>
• Tresoldi E, Dell'Albani I, Stabilini A, Jofra T, Valle A, Gagliani N, Bondanza A, Roncarolo MG, Battaglia M: Stability of human rapamycin‑expanded CD4+CD25+ T regulatory cells. Haematologica. 2011·Sep; 96(9):1357‑65. <·PMID:·21565906·>
• Wong EB, Akilimali NA, Govender P, Sullivan ZA, Cosgrove C, Pillay M, Lewinsohn DM, Bishai WR, Walker BD, Ndung'u T, Klenerman P, Kasprowicz VO: Low Levels of Peripheral CD161++CD8+ Mucosal Associated Invariant T (MAIT) Cells Are Found in HIV and HIV/TB Co‑Infection. PLoS·One. 2013·Dec·31; 8(12):e83474. <·PMID:·24391773·>