特異性

The mouse monoclonal antibody EGFR1 recognizes extracellular domain of human protein kinase EGFR; epitope within amino acids 6-273.

抗原情報

The oncoprotein EGFR (epidermal growth factor receptor), also known as HER1 or ErbB1, is a member of ErbB family of cell surface receptor tyrosine kinases. This 170 kDa transmembrane glycoprotein is often associated with cancerogenesis, although its activation state is controlled at various levels including trafficking and degradation steps. Binding of receptor-specific ligands to the EGFR ectodomain results in formation of homodimeric or heterodimeric kinase-active complexes into which HER2/ErbB2 is recruited as a preferred partner. Subsequent signaling cascades such as RAS/MAPK and PI3K/AKT pathways lead to cell proliferation and survival responses.

利用方法

保存方法

Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.

安定性情報

Do not use after expiration date stamped on vial label.

レファレンス

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• Akiyama M, Smith LT, Shimizu H: Changing patterns of localization of putative stem cells in developing human hair follicles. J·Invest·Dermatol. 2000·Feb; 114(2):321‑7. <·PMID:·10651993·>
• Fortunel NO, Hatzfeld JA, Rosemary PA, Ferraris C, Monier MN, Haydont V, Longuet J, Brethon B, Lim B, Castiel I, Schmidt R, Hatzfeld A: Long‑term expansion of human functional epidermal precursor cells: promotion of extensive amplification by low TGF‑beta1 concentrations. J·Cell·Sci. 2003·Oct·1; 116(19):4043‑52. <·PMID:·12953061·>
• Rebetz J, Tian D, Persson A, Widegren B, Salford LG, Englund E, Gisselsson D, Fan X: Glial progenitor‑like phenotype in low‑grade glioma and enhanced CD133‑expression and neuronal lineage differentiation potential in high‑grade glioma. PLoS·One. 2008·Apr·9; 3(4):e1936. <·PMID:·18398462·>