特異性

The mouse monoclonal antibody MAb11 recognizes human 17-26 kDa cytokine TNF α (tumor necrosis factor α).

抗原情報

TNF α is a cytokine produced by monocytes, macrophages, neutrophils, NK cells, CD4+ T cells and many transformed cells. It can be expressed as a 17 kDa free molecule, or as a 26 kDa membrane protein. TNF α easily forms stable trimers, but also other multimeric complexes. In the immune system, it is an important regulator, which has cytolytic and cytostatic activity against a range of tumor cells, increases fibroblast proliferation and supports neutrophil chemotaxis and phagocytosis.

利用方法

保存方法

Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.

安定性情報

Do not use after expiration date stamped on vial label.

レファレンス

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• Cesaro-Tadic S, Dernick G, Juncker D, Buurman G, Kropshofer H, Michel B, Fattinger C, Delamarche E: High‑sensitivity miniaturized immunoassays for tumor necrosis factor alpha using microfluidic systems. Lab·Chip. 2004·Dec; 4(6):563‑9. <·PMID:·15570366·>
• Visser J, Graffelman W, Blauw B, Haspels I, Lentjes E, de Kloet ER, Nagelkerken L: LPS‑induced IL‑10 production in whole blood cultures from chronic fatigue syndrome patients is increased but supersensitive to inhibition by dexamethasone. J·Neuroimmunol. 2001·Oct·1; 119(2):343‑9. <·PMID:·11585638·>
• Wahlström J, Katchar K, Wigzell H, Olerup O, Eklund A, Grunewald J: Analysis of intracellular cytokines in CD4+ and CD8+ lung and blood T cells in sarcoidosis. Am·J·Respir·Crit·Care·Med. 2001·Jan; 163(1):115‑21. <·PMID:·11208635·>
• Yan SR, Qing G, Byers DM, Stadnyk AW, Al-Hertani W, Bortolussi R: Role of MyD88 in diminished tumor necrosis factor alpha production by newborn mononuclear cells in response to lipopolysaccharide. Infect·Immun. 2004·Mar; 72(3):1223‑9. <·PMID:·14977922·>