CyFlow DLL4 Low Endotoxin (RUO)
| 品番 | BD560009 | ||
|---|---|---|---|
| 抗体名 | Anti-Hu DLL4 LOW END,MHD4-46 | ||
| 包装単位 | 0.1 mg | ||
| 濃度 | 1 mg/ml | ||
| 推奨使用量 | - | ||
| 容量 | 0.1 ml | ||
| 関連製品 (アイソタイプコントロール) |
Mouse IgG1 Low Endotoxin (AK478344) |
||
| 反応性|交差吸着 | Human | レーザー | - |
| 抗原 | DLL4 | 最大蛍光波長 | - |
| クローン | MHD4-46 | 最大励起波長 | - |
| ホスト | Mouse | 標識/Format | Low Endotoxin |
| アイソタイプ | IgG1 | 研究分野 | Immunophenotyping |
| クローナリティ | monoclonal | アプリケーション | - |
Anti-Hu DLL4 LOW END,MHD4-46
特異性
The mouse monoclonal antibody MHD4-46 recognizes the extracellular domain of DLL4 (δ-like ligand 4) antigen, a type I transmembrane protein which plays an important role in vascular development.
抗原情報
DLL4 (δ-like ligand 4) is one of five ligands of Notch receptors. It interacts with Notch1 and Notch4. DLL4 is up-regulated at sites of physiologic and pathologic angiogenesis, whereas its expression is low in most adult normal tissues. It is also highly expressed in human clear-cell renal carcinomas, bladder cancers, and breast cancers. Blocking the DLL4-Notch interaction seems to be a promising therapeutic approach.
利用方法
保存方法
Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
安定性情報
Do not use after expiration date stamped on vial label.
レファレンス
• Oishi H, Sunamura M, Egawa S, Motoi F, Unno M, Furukawa T, Habib NA, Yagita H: Blockade of delta‑like ligand 4 signaling inhibits both growth and angiogenesis of pancreatic cancer. Pancreas. 2010·Aug; 39(6):897‑903. <·PMID:·20182391·>
• Sekine C, Koyanagi A, Koyama N, Hozumi K, Chiba S, Yagita H: Differential regulation of osteoclastogenesis by Notch2/Delta‑like 1 and Notch1/Jagged1 axes. Arthritis·Res·Ther. 2012·Mar·5; 14(2):R45. <·PMID:·22390640·>
• Yamanda S, Ebihara S, Asada M, Okazaki T, Niu K, Ebihara T, Koyanagi A, Yamaguchi N, Yagita H, Arai H: Role of ephrinB2 in nonproductive angiogenesis induced by Delta‑like 4 blockade. Blood. 2009·Apr·9; 113(15):3631‑9. <·PMID:·19218547·>