特異性

The mouse monoclonal antibody PK136 recognizes NK1.1 (CD161bc) antigen (NK cell marker) expressed by some mouse strains (e.g. C57BL/6, NZB, CE, C58, Ma/My), whereas other strains (e.g. BALB/c, AKR, CBA, C3H) do not express this antigen. This antibody detects a conformational epitope on Nkrp1c and Nkrp1b gene products.

抗原情報

NK1.1 (CD161bc and also known as NKRP1, Ly55c, or Ly59) is a cell surface antigen expressed on NK cells and NK-T cells of certain mouse strains, which is being used for identification or antibody-mediated depletion of these cells in the respective strains. This antigen participates in NK cell activation, including production of interferon gamma, and release of cytotoxic granules.

利用方法

保存方法

Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.

安定性情報

Do not use after expiration date stamped on vial label.

レファレンス

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• Carroll JL, Nielsen LL, Pruett SB, Mathis JM: The role of natural killer cells in adenovirus‑mediated p53 gene therapy. Mol·Cancer·Ther. 2001·Nov; 1(1):49‑60. <·PMID:·12467238·>
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• Takahashi S, Kawamura T, Kanda Y, Taniguchi T, Nishizawa T, Iiai T, Hatakeyama K, Abo T: Activation of CD1d‑independent NK1.1+ T cells in the large intestine by Lactobacilli. Immunol·Lett. 2006·Jan·15; 102(1):74‑8. <·PMID:·16107279·>
• Wang M, Ellison CA, Gartner JG, HayGlass KT: Natural killer cell depletion fails to influence initial CD4 T cell commitment in vivo in exogenous antigen‑stimulated cytokine and antibody responses. J·Immunol. 1998·Feb·1; 160(3):1098‑105. <·PMID:·9570522·>