特異性

The mouse monoclonal antibody SY11B5 recognizes CD157 antigen, a 45 kDa GPI-anchored protein expressed mainly on monocytes, macrophages, granulocytes and bone marrow stromal cells.

抗原情報

CD157 (cADPr hydrolase 2) is a GPI-anchored ectoenzyme possessing ADP-ribosyl cyclase and cyclic ADP-ribose hydrolase activity. It uses NAD and cADP-ribose as substrates. CD157 is expressed on granulocytes, monocytes, macrophages, follicular dendritic cells, bone marrow stromal cells and human umbilical cord vein endothelial cells. In case of rheumatoid arthritis is expression is often higher and it is also differentially expressed in the myeloid leukemias. It may also have a signaling role.

利用方法

保存方法

Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.

安定性情報

Do not use after expiration date stamped on vial label.

レファレンス

• Arriga R, Caratelli S, Coppola A, Spagnoli GC, Venditti A, Amadori S, Lanzilli G, Lauro D, Palomba P, Sconocchia T, Del Principe MI: Enhancement of anti-leukemia activity of NK cells in vitro and in vivo by inhibition of leukemia cell-induced NK cell damage. Oncotarget. 2016·Jan·12; 7(2):2070. <·PMID:·26655503·>
• Sutherland DR, Acton E, Keeney M, Davis BH, Illingworth A: Use of CD in FLAER‐based assays for high‐sensitivity PNH granulocyte and PNH monocyte detection. Cytometry·Part·B:·Clinical·Cytometry. 2014·Jan·1; 86(1):44-55. <·PMID:·23922226·>
• Sutherland R, Acton E, Keeney M, Borowitz M, Richards S, Fletcher M, Whitby L, Barnett D, Illingworth A: Recommended antibody clones and conjugates suitable for high-sensitivity flow cytometric detection of PNH Red (RBC) and White (WBC) Blood Cells. Cytometry·Part·B:·Clinical·Cytometry. 2013 Nov 1; 84(6):422-3. <·No·PMID·>
• Marinov I, Kohoutová M, Tkáčová V, Pešek A, Čermák J, Cetkovský P: Clinical relevance of CD for rapid and cost‐effective simultaneous evaluation of PNH granulocytes and monocytes by flow cytometry. Int·J·Lab·Hematol. 2015·Apr; 37(2):231-7. <·PMID:·24963875·>
• Marinov I, Illingworth AJ, Benko M, Sutherland DR: Performance characteristics of a non‐FLAER‐based PNH assay for simultaneous evaluation of PNH neutrophils and PNH monocytes by flow cytometry, following published PNH guidelines. Cytometry·B·Clin·Cytom. 2016·Jun·13; <·PMID:·27294344·>