特異性

The mouse monoclonal antibody MEM-216 recognizes CD361 antigen, almost uncharacterized type I transmembrane protein with broad leukocyte expression, mostly in myeloid and B cells.

抗原情報

CD361 (EVI2B; Ecotropic Viral Integration site 2B or EVDB), is a poorly characterized type I transmembrane protein, expressed from one of three genes embedded in intron 27b of the neurofibromatosis type 1 (NF1) gene. The DNA strand that is transcribed to produce CD361 is the complementary one to the strand encoding NF1. Murine homolog to human CD361 is associated with ecotropic viral insertions, which have been implicated in the expression of murine myeloid leukemias. CD361 has been also reported to be involved in melanocyte and keratinocyte differentiation. However, it is expressed mainly in peripheral blood and bone marrow.

利用方法

保存方法

Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.

安定性情報

Do not use after expiration date stamped on vial label.

レファレンス

• Kaufmann D, Gruener S, Braun F, Stark M, Griesser J, Hoffmeyer S, Bartelt B: EVI2B, a gene lying in an intron of the neurofibromatosis type 1 (NF1 gene, is as the NF1 gene involved in differentiation of melanocytes and keratinocytes and is overexpressed in cells derived from NF1 neurofibromas. DNA·Cell·Biol. 1999·May; 18(5):345‑56. <·PMID:·10360836·>
• Viskochil D, Cawthon R, O'Connell P, Xu GF, Stevens J, Culver M, Carey J, White R: The gene encoding the oligodendrocyte‑myelin glycoprotein is embedded within the neurofibromatosis type 1 gene. Mol·Cell·Biol. 1991·Feb; 11(2):906‑12. <·PMID:·1899288·>