特異性

The mouse monoclonal antibody AH9R7 recognizes CD129 antigen, a 57 kDa type I transmembrane glycoprotein expressed at low levels by lymphocytes, blood cell progenitors, eosinophils, mast cells, epithelial cells, muscle cells and neurons.

抗原情報

CD129 serves as the high affinity α subunit of IL-9 receptor (IL-9R α). It associates with CD132, the common γ chain shared by receptors of many different cytokines. CD129 is expressed at low levels by T and B cells, blood cell progenitors, eosinophils, mast cells, epithelial cells, muscle cells and neurons. Its signaling (through JAK/STAT pathways) results in proliferative and anti-apoptotic response, which is critical e.g. for intrathymic T cell development and survival of various cell types. The gene for CD129 is located at the pseudoautosomal regions of X and Y chromosomes and it may be related with the development of asthma.

利用方法

保存方法

Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.

安定性情報

Do not use after expiration date stamped on vial label.

レファレンス

• De Smedt M, Verhasselt B, Kerre T, Vanhecke D, Naessens E, Leclercq G, Renauld JC, Van Snick J, Plum J: Signals from the IL‑9 receptor are critical for the early stages of human intrathymic T cell development. J·Immunol. 2000·Feb·15; 164(4):1761‑7. <·PMID:·10657622·>
• Grasso L, Huang M, Sullivan CD, Messler CJ, Kiser MB, Dragwa CR, Holroyd KJ, Renauld JC, Levitt RC, Nicolaides NC: Molecular analysis of human interleukin‑9 receptor transcripts in peripheral blood mononuclear cells: Identification of a splice variant encoding for a nonfunctional cellsurface receptor. J·Biol·Chem. 1998·Sep·11; 273(37):24016‑24. <·PMID:·9727018·>
• Pilette C, Ouadrhiri Y, Van Snick J, Renauld JC, Staquet P, Vaerman JP, Sibille Y: Oxidative burst in lipopolysaccharide‑activated human alveolar macrophages is inhibited by interleukin‑9. Eur·Respir·J. 2002·Nov; 20(5):1198‑205. <·PMID:·12449174·>
• Pilette C, Ouadrhiri Y, Van Snick J, Renauld JC, Staquet P, Vaerman JP, Sibille Y: IL‑9 inhibits oxidative burst and TNF‑alpha release in lipopolysaccharide‑stimulated human monocytes through TGF‑beta. J·Immunol. 2002·Apr·15; 168(8):4103‑11. <·PMID:·11937570·>