CyFlow PCLO Purified (RUO)
| 品番 | CD579636 | ||
|---|---|---|---|
| 抗体名 | Anti-Hu PCLO PURI,PCLO-01 | ||
| 包装単位 | 0.1 mg | ||
| 濃度 | 1 mg/ml | ||
| 推奨使用量 | - | ||
| 容量 | 0.1 ml | ||
| 関連製品 (アイソタイプコントロール) |
- | ||
| 反応性|交差吸着 | Human | レーザー | - |
| 抗原 | PCLO | 最大蛍光波長 | - |
| クローン | PCLO-01 | 最大励起波長 | - |
| ホスト | Mouse | 標識/Format | Purified |
| アイソタイプ | IgG1 | 研究分野 | Adaptor proteins | Neurobiology |
| クローナリティ | monoclonal | アプリケーション | - |
Anti-Hu PCLO PURI,PCLO-01
特異性
The mouse monoclonal antibody PCLO-01 recognizes PCLO (Piccolo) antigen, a more than 400 kDa multidomain protein expressed mainly in the presynaptic cytomatrix of the neurons.
抗原情報
PCLO (piccolo, aczonin) is a large (more than 400 kDa) multidomain protein of the presynaptic cytomatrix in neurons, that is present in all vertebrate synapses, but is absent from invertebrates. It contains zinc finger and coiled-coil sequences, as well as N-terminal glutamine-rich sequence, and C-terminal PDZ domain followed by two C2 domains (C2A and C2B). In vitro binding and transfection experiments suggested that PCLO binds to multiple proteins including profilin and L-type calcium channels. It is involved in neurotransmitter release and insulin secretion.
利用方法
保存方法
Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
安定性情報
Do not use after expiration date stamped on vial label.
レファレンス
• Dresbach T, Torres V, Wittenmayer N, Altrock WD, Zamorano P, Zuschratter W, Nawrotzki R, Ziv NE, Garner CC, Gundelfinger ED: Assembly of active zone precursor vesicles: obligatory trafficking of presynaptic cytomatrix proteins Bassoon and Piccolo via a trans‑Golgi compartment. J·BiolChem. 2006·Mar·3; 281(9):6038‑47. <·PMID:·16373352·>
• Mukherjee K, Yang X, Gerber SH, Kwon HB, Ho A, Castillo PE, Liu X, Südhof TC: Piccolo and bassoon maintain synaptic vesicle clustering without directly participating in vesicle exocytosis. Proc·Natl·Acad·Sci·USA. 2010·Apr·6; 107(14):6504‑9. <·PMID:·20332206·>