特異性

The mouse monoclonal antibody 323/A3 recognizes CD326 (EpCAM), a marker of epithelial lineages, that is over-expressed in many carcinomas.

抗原情報

CD326 (EpCAM, ESA, EGP40, EGP-2, KSA1/4, CO17-1A, GA733-2, MOC31, Ber-EP4) is a 40 kDa transmembrane glycoprotein serving as adhesion molecule in the basolateral membranes in a variety of epithelial cells. CD326 mediates calcium-independent homotypic cell-cell adhesions. CD326 over-expression has been detected in many epithelial tumors and is often associated with bad prognosis. It has been used for diagnostics of (pre-) malignancies at early stages.

利用方法

保存方法

Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.

安定性情報

Do not use after expiration date stamped on vial label.

レファレンス

• Balzar M, Bakker HA, Briaire-de-Bruijn IH, Fleuren GJ, Warnaar SO, Litvinov SV: Cytoplasmic tail regulates the intercellular adhesion function of the epithelial cell adhesion molecule. Mol·Cell·Biol. 1998·Aug; 18(8):4833‑43. <·PMID:·9671492·>
• Balzar M, Briaire-de Bruijn IH, Rees-Bakker HA, Prins FA, Helfrich W, de Leij L, Riethmüller G, Alberti S, Warnaar SO, Fleuren GJ, Litvinov SV: Epidermal growth factor‑like repeats mediate lateral and reciprocal interactions of Ep‑CAM molecules in homophilic adhesions. Mol·Cell·Biol. 2001·Apr; 21(7):2570‑80. <·PMID:·11259604·>
• Edwards DP, Grzyb KT, Dressler LG, Mansel RE, Zava DT, Sledge GW Jr, McGuire WL: Monoclonal antibody identification and characterization of a Mr 43,000 membrane glycoprotein associated with human breast cancer. Cancer·Res. 1986·Mar; 46(3):1306‑17. <·PMID:·3510721·>
• Kirman I, Jenkins D, Fowler R, Whelan RL: Naturally occurring antibodies to epithelial cell adhesion molecule (EpCAM). Dig·Dis·Sci. 2003·Dec; 48(12):2306‑9. <·PMID:·14714617·>
• Litvinov SV, Bakker HA, Gourevitch MM, Velders MP, Warnaar SO: Evidence for a role of the epithelial glycoprotein 40 (Ep‑CAM) in epithelial cell‑cell adhesion. Cell·Adhes·Commun. 1994·Oct; 2(5):417‑28. <·PMID:·7842256·>
• Litvinov SV, Velders MP, Bakker HA, Fleuren GJ, Warnaar SO: Ep‑CAM: a human epithelial antigen is a homophilic cell‑cell adhesion molecule. J·Cell·Biol. 1994·Apr; 125(2):437‑46. <·PMID:·8163559·>
• Winter MJ, Nagtegaal ID, van Krieken JH, Litvinov SV: The epithelial cell adhesion molecule (Ep‑CAM) as a morphoregulatory molecule is a tool in surgical pathology. Am·J·Pathol. 2003·Dec; 163(6):2139‑48. <·PMID:·14633587·>