CyFlow CD129 PE (RUO)
| 品番 | CE042379 | ||
|---|---|---|---|
| 抗体名 | Anti-Hu CD129 PE,AH9R7 | ||
| 包装単位 | 100 tests | ||
| 濃度 | - | ||
| 推奨使用量 | - | ||
| 容量 | 1 ml | ||
| 関連製品 (アイソタイプコントロール) |
Mouse IgG2b PE (CP922237) |
||
| 反応性|交差吸着 | Human | レーザー | Blue, Green, Yellow |
| 抗原 | CD129, IL-9Ra, IL9R | 最大蛍光波長 | 576 nm |
| クローン | AH9R7 | 最大励起波長 | 496 nm, 565 nm |
| ホスト | Mouse | 標識/Format | PE |
| アイソタイプ | IgG2b | 研究分野 | Immunophenotyping | Signaling |
| クローナリティ | monoclonal | アプリケーション | - |
Anti-Hu CD129 PE,AH9R7
特異性
The mouse monoclonal antibody AH9R7 recognizes CD129 antigen, a 57 kDa type I transmembrane glycoprotein expressed at low levels by lymphocytes, blood cell progenitors, eosinophils, mast cells, epithelial cells, muscle cells and neurons.
抗原情報
CD129 serves as the high affinity α subunit of IL-9 receptor (IL-9R α). It associates with CD132, the common γ chain shared by receptors of many different cytokines. CD129 is expressed at low levels by T and B cells, blood cell progenitors, eosinophils, mast cells, epithelial cells, muscle cells and neurons. Its signaling (through JAK/STAT pathways) results in proliferative and anti-apoptotic response, which is critical e.g. for intrathymic T cell development and survival of various cell types. The gene for CD129 is located at the pseudoautosomal regions of X and Y chromosomes and it may be related with the development of asthma.
利用方法
The reagent is designed for Flow Cytometry analysis of human blood cells. Recommended usage is 10 µl reagent / 100 µl of whole blood or 10^6 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
保存方法
Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
安定性情報
Do not use after expiration date stamped on vial label.
レファレンス
• De Smedt M, Verhasselt B, Kerre T, Vanhecke D, Naessens E, Leclercq G, Renauld JC, Van Snick J, Plum J: Signals from the IL‑9 receptor are critical for the early stages of human intrathymic T cell development. J·Immunol. 2000·Feb·15; 164(4):1761‑7. <·PMID:·10657622·>
• Grasso L, Huang M, Sullivan CD, Messler CJ, Kiser MB, Dragwa CR, Holroyd KJ, Renauld JC, Levitt RC, Nicolaides NC: Molecular analysis of human interleukin‑9 receptor transcripts in peripheral blood mononuclear cells: Identification of a splice variant encoding for a nonfunctional cellsurface receptor. J·Biol·Chem. 1998·Sep·11; 273(37):24016‑24. <·PMID:·9727018·>
• Pilette C, Ouadrhiri Y, Van Snick J, Renauld JC, Staquet P, Vaerman JP, Sibille Y: Oxidative burst in lipopolysaccharide‑activated human alveolar macrophages is inhibited by interleukin‑9. Eur·Respir·J. 2002·Nov; 20(5):1198‑205. <·PMID:·12449174·>
• Pilette C, Ouadrhiri Y, Van Snick J, Renauld JC, Staquet P, Vaerman JP, Sibille Y: IL‑9 inhibits oxidative burst and TNF‑alpha release in lipopolysaccharide‑stimulated human monocytes through TGF‑beta. J·Immunol. 2002·Apr·15; 168(8):4103‑11. <·PMID:·11937570·>