特異性

The rat monoclonal antibody MWReg30 recognizes mouse CD41 antigen, a transmembrane glycoprotein (integrin family) composed of two chains GPIIb α (heavy chain; 120 kDa) and GPIIb β (light chain; 23 kDa). CD41 is mainly expressed on platelets and megakaryocytes.

抗原情報

CD41 (GPIIb; platelet glycoprotein IIb) is composed of two subunits (120 kDa GPIIb α and 23 kDa GPIIb β) that interact with CD61 in the presence of calcium to form a functional adhesive protein receptor. Upon blood vessel damage, this receptor binds to a variety of proteins including von Willebrand factor, fibrinogen, fibronectin and vitronectin. CD41 is mainly expressed on megakaryocyte-platelet lineage, but generally belongs to the antigens that are expressed during early stages of hematopoietic differentiation.

利用方法

保存方法

Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.

安定性情報

Do not use after expiration date stamped on vial label.

レファレンス

• Boisset JC, Clapes T, Van Der Linden R, Dzierzak E, Robin C: Integrin αIIb (CD4{01} plays a role in the maintenance of hematopoietic stem cell activity in the mouse embryonic aorta. Biol·Open. 2013·Apr·11; 2(5):525‑32. <·PMID:·23789102·>
• Brancaleone V, Gobbetti T, Cenac N, le Faouder P, Colom B, Flower RJ, Vergnolle N, Nourshargh S, Perretti M: A vasculo‑protective circuit centered on lipoxin A4 and aspirin‑triggered 15‑epi‑lipoxin A4 operative in murine microcirculation. Blood. 2013·Jul·25; 122(4):608‑17. <·PMID:·23733341·>
• Ramsey H, Zhang Q, Brown DE, Steensma DP, Lin CP, Wu MX: Stress‑induced hematopoietic failure in the absence of immediate early response gene X‑1. Haematologica. 2013·Sep·20; <·PMID:·23812939·>
• Sullivan BP, Wang R, Tawfik O, Luyendyk JP: Protective and damaging effects of platelets in acute cholestatic liver injury revealed by depletion and inhibition strategies. Toxicol·Sci. 2010·May; 115(1):286‑94. <·PMID:·20133375·>