特異性

The mouse monoclonal antibody CB30 recognizes CD66e antigen, a cell surface bound carcinoembryonic antigen mainly expressed on epithelial cells.

抗原情報

The CD66e (CEA) is a 180-200 kDa member of carcinoembryonic antigens, immunoglobulin supergene family and consists of a single N domain (structural homology to the immunoglobulin variable) and six immunoglobulin constant-like A (A1, A2, A3) and B domains (B1, B2, B3). Human CD66e is heavily glycosylated GPI anchored protein capable of both homophilic and heterophilic adhesion. Disease relevance: The CD66e may play a role in the process of metastasis of cancer cells. CD66e is found in serum and it is clinically used as a tumor marker for early detection of disease due to its expression in adenocarcinomas - potential target of tumor imaging and drug targeting.

利用方法

保存方法

Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.

安定性情報

Do not use after expiration date stamped on vial label.

レファレンス

• Chen CJ, Li LJ, Maruya A, Shively JE: In vitro and in vivo footprint analysis of the promoter of carcinoembryonic antigen in colon carcinoma cells: effects of interferon gamma treatment. Cancer·Res. 1995·Sep·1; 55(17):3873‑82. <·PMID:·7641207·>
• Gangopadhyay A, Bajenova O, Kelly TM, Thomas P: Carcinoembryonic antigen induces cytokine expression in Kuppfer cells: implications for hepatic metastasis from colorectal cancer. Cancer·Res. 1996·Oct·15; 56(20):4805‑10. <·PMID:·8841002·>
• Oikawa S, Nakazato H, Kosaki G: Primary structure of human carcinoembryonic antigen (CEA) deduced from cDNA sequence. Biochem·Biophys·Res·Commun. 1987·Jan·30; 142(2):511‑8. <·PMID:·3814146·>
• Thompson JA, Grunert F, Zimmermann W: Carcinoembryonic antigen gene family: molecular biology and clinical perspectives. J·Clin·Lab·Anal. 1991; 5(5):344‑66. <·PMID:·1941355·>