特異性

The mouse monoclonal antibody 87G recognizes both membrane-bound and soluble forms of HLA-G (HLA-G1 and HLA-G5). HLA-G belongs to the MHC Class I molecules (MHC Class Ib; nonclassical) and it is expressed on the surface of trophoblast cells. The antibody 87G blocks interaction of HLA-G with inhibitory receptors.

抗原情報

利用方法

保存方法

Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.

安定性情報

Do not use after expiration date stamped on vial label.

レファレンス

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• Ishitani A, Sageshima N, Lee N, Dorofeeva N, Hatake K, Marquardt H, Geraghty DE: Protein Expression and Peptide Binding Suggest Unique and Interacting Functional Roles for HLA‑E, F and G in Maternal‑Placental Immune Recognitions. J·Immunol. 2003; 171:1376. <·PMID:·12874228·>
• Lee N, Malacko AR, Ishitani A, Chen MC, Bajorath J, Marquardt H, Geraghty DE: The membrane‑bound and soluble forms of HLA‑G bind identical sets of endogenous peptides but differ with respect to TAP association. Immunity. 1995; 3(5):591‑600. <·PMID:·7584149·>
• LeMaoult J, Caumartin J, Daouya M, Favier B, Le Rond S, Gonzalez A, Carosella ED: Immune regulation by pretenders: cell‑to‑cell transfers of HLA‑G make effector T cells act as regulatory cells. Blood. 2007·Mar·1; 109(5):2040‑8. <·PMID:·17077329·>
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• Polakova K, Krcova M, Kuba D, Russ G: Analysis of HLA‑G expression in malignant hematopoetic cells from leukemia patients. Leuk·Res. 2003·Jul; 27(7):643‑8. <·PMID:·12681364·>
• Riteau B, Menier C, Khalil-Daher I, Martinozzi S, Pla M, Dausset J, Carosella ED, Rouas-Freiss N: HLA‑G1 co‑expression boosts the HLA class I‑mediated NK lysis inhibition. Int·Immunol. 2001·Feb; 13(2):193‑201. <·PMID:·11157852·>
• Rouas-Freiss N, Moreau P, Ferrone S, Carosella ED: HLA‑G proteins in cancer: do they provide tumor cells with an escape mechanism?. Cancer·Res. 2005·Nov·15; 65(22):10139‑44. <·PMID:·16287995·>
• Sageshima N, Ishitani A, Omura M, Akasaki M, Umekage H, Katabuchi H, Okamura H, Hatake K: Necrotic feature of the trophoblasts lacking HLA‑G expression in normal andpre‑eclamptic placentas. Am·J·Reprod·Immunol. 2003·Mar; 49(3):174‑82. <·PMID:·12797524·>
• Shobu T, Sageshima N, Tokui H, Omura M, Saito K, Nagatsuka Y, Nakanishi M, Hayashi Y, Hatake K, Ishitani A: The surface expression of HLA‑F on decidual trophoblasts increases from mid to term gestation. J·Reprod·Immunol. 2006·Dec; 72(1‑2):18‑32. <·PMID:·16806485·>
• Wiendl H: The non‑classical MHC molecule HLA‑G protects human muscle cells from immune‑mediated lysis: implications for myoblast transplantation and gene therapy. Brain. 2003; 126(1):176‑85. <·PMID:·12477705·>