特異性

The mouse monoclonal antibody E11 recognizes CD35 antigen, a type I glycoprotein expressed on granulocytes, monocytes, B cells, folicular dendritic cells, erythrocytes, NK and T cell subsets, as well as e.g. on glomerulal podocytes.

抗原情報

CD35 (CR1; complement receptor 1) is a monomeric multiple modular cell surface glycoprotein which serves as receptor for C3b and C4b, the most important components of the complement system leading to clearance of foreign macromolecules. It is expressed mainly on the surface of granulocytes, monocytes, erythrocytes, B cells and folicular dendritic cells. Besides its role in complement cascade, CD35 is involved in blocking BCR-induced proliferation and the differentiation of B cells to plasmablasts and their Ig production.

利用方法

保存方法

Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.

安定性情報

Do not use after expiration date stamped on vial label.

レファレンス

• Hogg N, Ross GD, Jones DB, Slusarenko M, Walport MJ, Lachmann PJ: Identification of an anti‑monocyte monoclonal antibody that is specific for membrane complement receptor type one (CR1). Eur·J·Immunol. 1984·Mar; 14(3):236‑43. <·PMID:·6368248·>
• Kremlitzka M, Polgár A, Fülöp L, Kiss E, Poór G, Erdei A: Complement receptor type 1 (CR1, CD35 is a potent inhibitor of B‑cell functions in rheumatoid arthritis patients. Int·Immunol. 2013·Jan; 25(1):25‑33. <·PMID:·22962438·>
• Nielsen CH, Pedersen ML, Marquart HV, Prodinger WM, Leslie RG: The role of complement receptors type 1 (CR1, CD35 and 2 (CR2, CD21 in promoting C3 fragment deposition and membrane attack complex formation on normal peripheral human B cells. Eur·J·Immunol. 2002·May; 32(5):1359‑67. <·PMID:·11981823·>
• McMichael AJ, Beverley PCL, Cobbold S, et al (Eds): Leucocyte Typing III, White Cell Differentiation Antigens. Oxford·University·Press,·Oxford. 1987; 1‑1050. <·NLM·ID:·8913266·>